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KMID : 0043319960190040307
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Archives of Pharmacal Research
1996 Volume.19 No. 4 p.307 ~ p.311
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Regioselective synthesis of .alpha.-L-fucosyl-containing benzyl disaccharides by use of .alpha.-L-fucosidases of aspergillus niger
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Chung Yong-Za
Kwak Hong-Keun
Sung Yung-Ki
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Abstract
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The activity of fucosidase shows different value depending on disease, eg) fucosidosis and I cell disease are characterized by the absence or deficiences of .alpha.-fucosidase, and sera of ovarian cancer patients exhibited a statistically significant deficiency of .alpha.-L-fucosidase activity (Zielke et al., 1972; Kress et al., 1980; Barlow et al., 1981). For the purpose of diagnosis of these disease easily, the manual of test can be developed by preparing kits of hydrophobic-binding substrate of fucosidase that bind C18-column.
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KEYWORD
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Regioselective synthesis, Fucosidase, Aspergillus niger, Fucosyl containg ben-zyldisaccharides, PNP-fucopyranoside
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